pentobarbital improves toxicity of buprenorphine, long-performing injection by pharmacodynamic synergism. Modify Therapy/Watch Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants will increase threat of adverse reactions like overdose, respiratory melancholy, and Loss of life. Cessation of benzodiazepines or other CNS depressants is chosen normally.
pentobarbital will minimize the level or effect of ibuprofen by influencing hepatic enzyme CYP2C9/10 metabolism. Minimal/Significance Unfamiliar.
pentobarbital will lower the extent or result of midazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will minimize the level or influence of alosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.
pentobarbital will minimize the extent or outcome of fosphenytoin by impacting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Observe.
pentobarbital will decrease the extent or effect of temsirolimus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
With therapeutic doses of TCAs, barbiturates raise metabolism and decrease blood concentrations of TCAs.
pentobarbital will raise the level or effect of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital decreases levels of toremifene by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. CYP3A4 inducers improve amount of toremifene metabolism, lowering the continual-state concentration in serum.
pentobarbital will decrease the extent or impact of estradiol vaginal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will lessen the level or result of alfentanil by influencing hepatic/intestinal enzyme CYP3A4 more info metabolism. Minor/Significance Mysterious.
pentobarbital will lower the extent or impact of tramadol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Diminished AUC of tramadol and the active metabolite (O-desmethyltramadol) when coadministered with robust CYP3A4 and CYP2B6 inducers
With therapeutic doses of TCAs, barbiturates enhance metabolism and decrease blood concentrations of TCAs.
pentobarbital will reduce the extent or result of voriconazole by affecting hepatic enzyme CYP2C9/ten metabolism. Minimal/Significance Mysterious.